Not the book for detailed explications of the technology underlying the findings, but readers will appreciate the...

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DRAWING THE MAP OF LIFE

INSIDE THE HUMAN GENOME PROJECT

Veteran science writer McElheny (Watson and DNA, 2003, etc.) chronicles the history of genomics research.

A couple decades ago, the idea of the government supporting a project to map and sequence the whole human genome—locate where the genes are and specify the precise order of nucleotides that make up “the language of life”—was a gleam in the eye of a few stellar pioneers, but looked down upon by an equally stellar group of naysayers. With the advent of Big Biology in the ’90s, however, massive amounts of money poured into the National Institutes of Health, which, along with the Department of Energy and foundations abroad, supported international teams at multiple laboratories. Then came private competition in the form of American biologist and entrepreneur J. Craig Venter. McElheny devotes more than half the book to this narrative, which ends with the Clinton administration’s announcement of the completion of first drafts of the human genome by both Venter and the NIH’s Francis Collins in 2000. Throughout the book, the author provides well-developed profiles and anecdotes of the characters involved, but the real value is in McElheny’s enumeration of the astonishing complexities in human and other genomes revealed by today’s sophisticated technologies. Even the definition of a gene is no longer clear. There are split genes, noncoding sequences overlapping coded ones and much more, as well as lots of activity involving so-called junk DNA. Add epigenetics—the study of nongenetic factors that modify the action of genes—and scientists now have puzzles galore to inspire the next biological revolution.

Not the book for detailed explications of the technology underlying the findings, but readers will appreciate the implications of the new learning on evolution, agriculture, energy and prospects for “personalized medicine.”

Pub Date: July 1, 2010

ISBN: 978-0-465-04333-0

Page Count: 336

Publisher: Basic

Review Posted Online: June 3, 2010

Kirkus Reviews Issue: May 15, 2010

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Loads of good explaining, with reminders, time and again, of how much remains unknown, neatly putting the death of science...

A SHORT HISTORY OF NEARLY EVERYTHING

Bryson (I'm a Stranger Here Myself, 1999, etc.), a man who knows how to track down an explanation and make it confess, asks the hard questions of science—e.g., how did things get to be the way they are?—and, when possible, provides answers.

As he once went about making English intelligible, Bryson now attempts the same with the great moments of science, both the ideas themselves and their genesis, to resounding success. Piqued by his own ignorance on these matters, he’s egged on even more so by the people who’ve figured out—or think they’ve figured out—such things as what is in the center of the Earth. So he goes exploring, in the library and in company with scientists at work today, to get a grip on a range of topics from subatomic particles to cosmology. The aim is to deliver reports on these subjects in terms anyone can understand, and for the most part, it works. The most difficult is the nonintuitive material—time as part of space, say, or proteins inventing themselves spontaneously, without direction—and the quantum leaps unusual minds have made: as J.B.S. Haldane once put it, “The universe is not only queerer than we suppose; it is queerer than we can suppose.” Mostly, though, Bryson renders clear the evolution of continental drift, atomic structure, singularity, the extinction of the dinosaur, and a mighty host of other subjects in self-contained chapters that can be taken at a bite, rather than read wholesale. He delivers the human-interest angle on the scientists, and he keeps the reader laughing and willing to forge ahead, even over their heads: the human body, for instance, harboring enough energy “to explode with the force of thirty very large hydrogen bombs, assuming you knew how to liberate it and really wished to make a point.”

Loads of good explaining, with reminders, time and again, of how much remains unknown, neatly putting the death of science into perspective.

Pub Date: May 6, 2003

ISBN: 0-7679-0817-1

Page Count: 304

Publisher: Broadway

Review Posted Online: May 20, 2010

Kirkus Reviews Issue: April 1, 2003

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Jahren transcends both memoir and science writing in this literary fusion of both genres.

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LAB GIRL

Award-winning scientist Jahren (Geology and Geophysics/Univ. of Hawaii) delivers a personal memoir and a paean to the natural world.

The author’s father was a physics and earth science teacher who encouraged her play in the laboratory, and her mother was a student of English literature who nurtured her love of reading. Both of these early influences engrossingly combine in this adroit story of a dedication to science. Jahren’s journey from struggling student to struggling scientist has the narrative tension of a novel and characters she imbues with real depth. The heroes in this tale are the plants that the author studies, and throughout, she employs her facility with words to engage her readers. We learn much along the way—e.g., how the willow tree clones itself, the courage of a seed’s first root, the symbiotic relationship between trees and fungi, and the airborne signals used by trees in their ongoing war against insects. Trees are of key interest to Jahren, and at times she waxes poetic: “Each beginning is the end of a waiting. We are each given exactly one chance to be. Each of us is both impossible and inevitable. Every replete tree was first a seed that waited.” The author draws many parallels between her subjects and herself. This is her story, after all, and we are engaged beyond expectation as she relates her struggle in building and running laboratory after laboratory at the universities that have employed her. Present throughout is her lab partner, a disaffected genius named Bill, whom she recruited when she was a graduate student at Berkeley and with whom she’s worked ever since. The author’s tenacity, hope, and gratitude are all evident as she and Bill chase the sweetness of discovery in the face of the harsh economic realities of the research scientist.

Jahren transcends both memoir and science writing in this literary fusion of both genres.

Pub Date: April 5, 2016

ISBN: 978-1-101-87493-6

Page Count: 336

Publisher: Knopf

Review Posted Online: Jan. 5, 2016

Kirkus Reviews Issue: Jan. 15, 2016

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