By integrating themes of genetic research, ethical conundrums, unlawful death, and racial discrimination, this multifaceted...
A medical scientist conducts controversial experiments involving human memory and age with disastrous results.
Ten years in the making and an assured departure from the author’s Adirondack Trilogy, Holtzman’s (Forever Wild, 2013, etc.) fourth novel is effectively informed by his former career as a physician and geneticist. The tale opens with the death of Betsy Matthews, an African-American woman who perishes from leukemia as a result of her participation in a clinical trial sponsored by the local esteemed university and a financial backing corporation. The narrative flashes back to when Jason Pearce, the latest young, motivated faculty member of Virginia’s Bates-Bronsted Medical School, became obsessed with bankrolling his reputation for groundbreaking, National Institutes of Health–funded research into “gene regulation.” Personally, Audrey Meacham, an influential (and increasingly pessimistic) member of the collegiate administration, immediately captures his interest both scientifically and romantically. The two are married and have several children while Pearce continues his genetic experimentation. Holtzman cleverly infuses his protagonist with a smooth combination of clinical innovation and energized “path-breaking potential,” yet he also realizes these things require money, which seems to be the initial linchpin of the story. Pearce also exhibits a certain disdain for university politics and the manipulative biotech entities that dangle lucrative incentives above the heads of the medical school’s top scientists. That is, until he receives a timely and tempting offer he cannot refuse: to have his genetic research tied to Alzheimer’s disease fully funded by a venture capitalist firm that believes the scientist could be at the precipice of a groundbreaking discovery in human memory restoration. Once the literary groundwork is laid, the author gets to work amping up the suspense and the danger quotients concerning gene-therapy clinical trial volunteer Matthews, whose eventual fate throws Pearce’s formerly illustrious career and life into a harrowing tailspin of guilt and murderous negligence accusations.
By integrating themes of genetic research, ethical conundrums, unlawful death, and racial discrimination, this multifaceted novel delivers a brisk, riveting tale of greed and clinical malfeasance.Pub Date: Aug. 16, 2016
ISBN: 978-0-692-81019-4
Page Count: -
Publisher: Cloudsplitter Press
Review Posted Online: April 28, 2017
Review Program: Kirkus Indie
The phrase “tour de force” could have been invented for this audacious novel.
Four men who meet as college roommates move to New York and spend the next three decades gaining renown in their professions—as an architect, painter, actor and lawyer—and struggling with demons in their intertwined personal lives.
Yanagihara (The People in the Trees, 2013) takes the still-bold leap of writing about characters who don’t share her background; in addition to being male, JB is African-American, Malcolm has a black father and white mother, Willem is white, and “Jude’s race was undetermined”—deserted at birth, he was raised in a monastery and had an unspeakably traumatic childhood that’s revealed slowly over the course of the book. Two of them are gay, one straight and one bisexual. There isn’t a single significant female character, and for a long novel, there isn’t much plot. There aren’t even many markers of what’s happening in the outside world; Jude moves to a loft in SoHo as a young man, but we don’t see the neighborhood change from gritty artists’ enclave to glitzy tourist destination. What we get instead is an intensely interior look at the friends’ psyches and relationships, and it’s utterly enthralling. The four men think about work and creativity and success and failure; they cook for each other, compete with each other and jostle for each other’s affection. JB bases his entire artistic career on painting portraits of his friends, while Malcolm takes care of them by designing their apartments and houses. When Jude, as an adult, is adopted by his favorite Harvard law professor, his friends join him for Thanksgiving in Cambridge every year. And when Willem becomes a movie star, they all bask in his glow. Eventually, the tone darkens and the story narrows to focus on Jude as the pain of his past cuts deep into his carefully constructed life.
The phrase “tour de force” could have been invented for this audacious novel.Pub Date: March 10, 2015
ISBN: 978-0-385-53925-8
Page Count: 720
Publisher: Doubleday
Review Posted Online: Dec. 21, 2014
Kirkus Reviews Issue: Jan. 1, 2015
BOOK REVIEW
BOOK REVIEW
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Dated sermonizing on career versus motherhood, and conflict driven by characters’ willed helplessness, sap this tale of...
Lifelong, conflicted friendship of two women is the premise of Hannah’s maudlin latest (Magic Hour, 2006, etc.), again set in Washington State.
Tallulah “Tully” Hart, father unknown, is the daughter of a hippie, Cloud, who makes only intermittent appearances in her life. Tully takes refuge with the family of her “best friend forever,” Kate Mularkey, who compares herself unfavorably with Tully, in regards to looks and charisma. In college, “TullyandKate” pledge the same sorority and major in communications. Tully has a life goal for them both: They will become network TV anchorwomen. Tully lands an internship at KCPO-TV in Seattle and finagles a producing job for Kate. Kate no longer wishes to follow Tully into broadcasting and is more drawn to fiction writing, but she hesitates to tell her overbearing friend. Meanwhile a love triangle blooms at KCPO: Hard-bitten, irresistibly handsome, former war correspondent Johnny is clearly smitten with Tully. Expecting rejection, Kate keeps her infatuation with Johnny secret. When Tully lands a reporting job with a Today-like show, her career shifts into hyperdrive. Johnny and Kate had started an affair once Tully moved to Manhattan, and when Kate gets pregnant with daughter Marah, they marry. Kate is content as a stay-at-home mom, but frets about being Johnny’s second choice and about her unrealized writing ambitions. Tully becomes Seattle’s answer to Oprah. She hires Johnny, which spells riches for him and Kate. But Kate’s buttons are fully depressed by pitched battles over slutwear and curfews with teenaged Marah, who idolizes her godmother Tully. In an improbable twist, Tully invites Kate and Marah to resolve their differences on her show, only to blindside Kate by accusing her, on live TV, of overprotecting Marah. The BFFs are sundered. Tully’s latest attempt to salvage Cloud fails: The incorrigible, now geriatric hippie absconds once more. Just as Kate develops a spine, she’s given some devastating news. Will the friends reconcile before it’s too late?
Dated sermonizing on career versus motherhood, and conflict driven by characters’ willed helplessness, sap this tale of poignancy.Pub Date: Feb. 1, 2008
ISBN: 978-0-312-36408-3
Page Count: 496
Publisher: St. Martin's
Review Posted Online: May 19, 2010
Kirkus Reviews Issue: Nov. 1, 2007
BOOK TO SCREEN
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